Robert E. Gerszten M.D.

Inflammation and Biomarkers in Cardiovascular Disease

Dr. Gerszten’s research efforts focus on understanding the molecular basis of injury responses in cardiovascular disease. His laboratory has incorporated emerging proteomics and metabolomics technologies to help identify novel signals derived from leukocytes, endothelial cells, or from the myocardium. In ongoing translational studies, his group applies these same methodologies directly to samples from well-phenotyped human cohorts to identify candidate biomarkers, returning again to the bench to define functional roles. The research incorporates basic molecular and cell biology, chemistry and mass spectrometry, bioinformatics, all with a foundation in clinical medicine. The overall goal is to identify new metabolites and proteins that mark cardiovascular disease activity, shed insight into disease progression, and provide targets for therapeutic intervention.

References.

1. Rhee EP, Clish CB, Ghorbani A, Larson MG, Elmariah S, McCabe E, Yang Q, Cheng S, Pierce K, Deik A, Souza AL, Farrell L, Domos C, Yeh RW, Palacios I, Rosenfield K, Vasan RS, Florez JC, Wang TJ, Fox CS, Gerszten, RE. A Combined Epidemiologic and Metabolomic Approach Improves CKD Prediction. Journal of the American Society of Nephrology 2013 Jul;24(8):1330-8. PMID:23687356 PMCID:PMC3736702

2. Loffredo FS, Steinhauser ML, Jay SM, Gannon J, Pancoast JR, Yalamanchi P, Sinha M, Dall'Osso C, Khong D, Shadrach JL, Miller CM, Singer BS, Stewart A, Psychogios N, Gerszten RE, Hartigan AJ, Kim MJ, Serwold T, Wagers AJ, Lee RT. Growth Differentiation Factor 11 is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy. Cell 2013 May 9;153(4):828-39. PMID:23663781 PMCID:PMC3677132

3. Rhee EP, Ho JE, Chen MH, Shen D, Cheng S, Larson MG, Ghorbani A, Shi X, Helenius IT, O'Donnell CJ, Souza AL, Deik A, Pierce KA, Bullock K, Walford GA, Vasan RS, Florez JC, Clish C, Yeh JR, Wang TJ, Gerszten RE. A Genome-Wide Association Study of the Human Metabolome in a Community-Based Cohort Demonstrates Substantial Heritability of Circulating Metabolites. Cell Metabolism 2013 Jul 2;18(1):130-43. PMID:23823483

4. Wang TJ, Ngo D, Psychogios N, Dejam A, Larson M, Ramachandran V, Ghorbani A, O'Sullivan J, Cheng S, Rhee EP, Sinha S, McCabe E, Fox C, O'Donnell C, Ho J, Florez J, Magnusson M, Pierce K, Souza A, Yu Y, Carter C, Light P, Melander O, Clish C, Gerszten RE. 2-Aminoadipic acid is a biomarker for diabetes risk. Journal of Clinical Investigation 2013 Oct 1;123(10):4309-17. PMID:24091325 PMCID:PMC3784523

5. Rottiers V, Obad S, Petri A, McGarrah R, Lindholm MW, Black JC, Sinha S, Goody RJ, Lawrence MS, deLemos AS, Hansen HF, Whittaker S, Henry S, Brookes R, Najafi-Shoushtari SH, Chung RT, Whetstine JR, Gerszten RE, Kauppinen S, Näär AM. Pharmacological inhibition of a microRNA family in non-human primates by a seed-targeting 8-mer antimiR oligonucleotide. Science Translational Medicine 2013 Nov 20;5(212):212ra162. PMID: 24259050

6. Walford GA, David J, Warner AS, Ackerman RJ, Billings LK, Chamarthi, B, Fanelli RR, Hernandez AM, Huang C, Khan SQ, Littleton KR, Lo J, McCarthy RM, Rhee EP, Deik A, Stolerman E, Taylor A, Hudson MS, Wang TJ, Altshuler D, Grant RW, Clish CB, Gerszten RE, Florez JC. Branched chain and aromatic amino acids change acutely following two medical therapies for type 2 diabetes mellitus. Metabolism 2013 Dec;62(12):1772-8. PMID:23953891 PMCID: PMC3833885

7. Kalim S, Clish CB, Wenger J, Elmariah S, Yeh RW, Deferio JJ, Pierce K, Deik A, Gerszten RE, Thadhani R, Rhee EP. A plasma long-chain acylcarnitine predicts cardiovascular mortality in incident dialysis patients. J Am Heart Assoc. 2013 Dec 5;2(6):e000542. PMID:24308938 PMCID:PMC3886735

8. Roberts LD, Boström P, O’Sullivan JF, Schinzel RT, Lewis GD, Dejam A, Lee Y-K, Palma MJ, Calhoun S, Georgiadi A, Chen M-H, Ramachandran VS, Larson MG, Bouchard C, Rankinen T, Souza AL, Clish CB, Wang TJ, Estall JL, Soukas AA, Cowan CA, Spiegelman BM, Gerszten RE. β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-oxidation and is Inversely Correlated with Cardiometabolic Risk Factors. Cell Metabolism. 2014 Jan 7;19(1) ):96-108. PMID:24411942.

 

 

 

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