Eleftheria Maratos-Flier, M.D.

FGF21 and nutritional regulation of energy balance in obesity and fatty liver

My lab works on the regulation of energy balance in relation to the pathogenesis and treatment of obesity. Our current major focus is the regulation of both energy expenditure and nutrient partitioning and the role of the omnikine FGF21 in this process. We are also studying the pathways that result in fatty liver which contributes to the morbidity and mortality associated with the obese state. From a nutritional standpoint, we are interested in the contribution of fructose and sucrose to the development of fatty liver. Additionally, we are investigating the regulation of energy balance through the central nervous system with our primary focus being on hypothalamic neuropeptides. My lab is involved in both basic research with mouse models of obesity as well as several translational studies.

References.

1. Fisher FM, Chui PC, Antonellis PJ, Bina HA, Kharitonenkov A, Flier JS, Maratos-Flier E. Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State. Diabetes. 2010 Nov;59(11):2781-9. PMCID: PMC2963536

2. Domouzoglou EM, Maratos-Flier E. Fibroblast growth factor 21 is a metabolic regulator that plays a role in the adaptation to ketosis. Am J Clin Nutr. 2011 Apr;93(4):901S-5. PMCID: PMC3057552

3. Fisher FM, Estall JL, Adams AC, Antonellis PJ, Bina HA, Flier JS, Kharitonenkov A, Spiegelman BM, Maratos-Flier E. Integrated Regulation of Hepatic Metabolism by Fibroblast Growth Factor 21 (FGF21) in Vivo. Endocrinology. 2011 Aug;152(8):2996-3004. PMCID: PMC3138239

4. Dushay J, Gao C, Gopalakrishnan GS, Crawley M, Mitten EK, Wilker E, Mullington J, Maratos-Flier E. Short-Term Exenatide Treatment Leads to Significant Weight Loss in a Subset of Obese Women Without Diabetes. Diabetes Care. 2012 Jan;35(1):4-11. PMCID: PMC3241299

5. Fisher FM, Kleiner S, Douris N, Fox EC, Mepani RJ, Verdeguer F, Wu J, Kharitonenkov A, Flier JS, Maratos-Flier E, Spiegelman BM. FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis. Genes Dev. 2012 Feb 1;26(3):271-81. PMCID: PMC3278894.

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