Valentina Perissi , PhD
I direct a robust research program focused on dissecting the molecular mechanisms that control adaptive responses to metabolic stress and pro-inflammatory signals in adipose tissue, immune cells and breast cancer. To achieve this goal, we use a combination of basic molecular biology and biochemical approaches (site-specific mutagenesis, CRISPR editing, gene expression analyses, protein-protein interaction studies, in vitro enzymatic assays), next generation sequencing (ChIPseq, RNAseq, GROseq) and in vivo studies (tissue-specific mouse models, dietary challenges, cold exposure, tumor xenografts). Since 2017 I also serve as co-Director of the BNORC Adipose Biology and Nutrient Metabolism Core which provide access to mouse and human adipocytes/pre-adipocytes and banked tissues, and consultation/training for applications related to adipose tissue biology, obesity and nutrition to BNORC members in the broad Boston area.
1. Cardamone MD, et.al. A protective strategy
against hyperinflammatory responses requiring the
non-transcriptional actions of GPS2. Molecular Cell,