Clifford B. Saper, MD PhD

My research program is on the neural circuits that control basic life functions, including sleep-wake, circadian rhythms, thermoregulation, feeding and metabolism, and stress.  In particular, we have identified circuits in the brain controlling circadian rhythms of feeding and thermoregulation (which is a major participant in energy metabolism).

References:

1. Machado NLS et.al., A Glutamatergic Hypothalamomedullary Circuit Mediates Thermogenesis, but Not Heat Conservation, during Stress-Induced Hyperthermia. Curr Biol. 2018;28:2291-2301

2. Todd WD et.al., A hypothalamic circuit for the circadian control of aggression. Nat Neurosci. 2018;21:717-724.

3. Abbott SBG, Saper CB. Role of the median preoptic nucleus in the autonomic response to heat-exposure. Temperature (Austin). 2018 Feb 6;5(1):4-6.









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